Lymphocytic Responses to Streptococcal Antigens in Glomerulonephritic Patients

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Science  29 May 1970:
Vol. 168, Issue 3935, pp. 1105-1108
DOI: 10.1126/science.168.3935.1105


The lymphocytes from patients with progressive glomerulonephritis showed significant inhibition of cell migration in the presence of group A streptococcal particulate antigens. Marked increases in the level of DNA synthesis of these lymphocytes were also observed after contact with these antigens. Lymphocytes from patients with unrelated renal disorders exhibited minimum reactivity to streptococcal antigens.

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