Intracranial Self-Stimulation and Wakefulness: Effect of Manipulating Ambient Brain Catecholamines

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Science  12 Jun 1970:
Vol. 168, Issue 3937, pp. 1370-1372
DOI: 10.1126/science.168.3937.1370


Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward.

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