Diphenylhydantoin and Diazepam: Molecular Structure Similarities and Steric Basis of Anticonvulsant Activity

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Science  19 Jun 1970:
Vol. 168, Issue 3938, pp. 1457-1458
DOI: 10.1126/science.168.3938.1457


Diphenylhydantoin and diazepam are two useful antiepileptic drugs. Though not obviously related chemically, their molecular conformations exhibit marked similarities. These similarities indicate a steric basis for their anticonvulsant activity and lead to conclusions about the receptor sites for this type of pharmaceutical.

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