Mouse Lysozyme Production by a Monocytoma: Isolation and Comparison with Other Lysozymes

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Science  26 Jun 1970:
Vol. 168, Issue 3939, pp. 1595-1597
DOI: 10.1126/science.168.3939.1595


A transplantable mouse tumor, GPC-11, produces large amounts of lysozyme. The tumor is a reticulum cell sarcoma, type A, and is a neoplasm of monocytes. The lysozyme was purified from mouse urine in quantities sufficient for structural analysis. Comparison of mouse lysozyme with lysozymes from; chicken egg white and patients with monocytic leukemia reveals similarities in size and electrophoretic mobility and, with human lysozyme, in functional properties; but considerable differences are found in antigenic characteristics and amino acid composition.

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