Impairment of Shock Avoidance Learning after Long-Term Alcohol Ingestion in Mice

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Science  26 Jun 1970:
Vol. 168, Issue 3939, pp. 1599-1601
DOI: 10.1126/science.168.3939.1599


Chronic alcohol consumption impaired the learning of a two-way shuttle box avoidance task in mice 10 to 14 days after the discontinuation of ethanol in the diet. Control groups received laboratory chow ad libitum or were pair-fed with the alcohol-consuming mice by diets containing isocaloric amounts of sucrose. The performance of the two control groups was indistinguishable from each other, and only the ethanol-consuming mice performed poorly. It was therefore concluded that alcohol consumption per se and not a nutritional deficiency was responsible for the impairment of learning.

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