Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes

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Science  10 Jul 1970:
Vol. 169, Issue 3941, pp. 198-201
DOI: 10.1126/science.169.3941.198


Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams per day) over a 1-month period. No significant increase in chromosome aberrations was detected in vitro or in vivo.

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