Amantadine-Dopamine Interaction: Possible Mode of Action in Parkinsonism

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Science  10 Jul 1970:
Vol. 169, Issue 3941, pp. 203-204
DOI: 10.1126/science.169.3941.203


Intravenous doses of amantadine hydrochloride, an antiviral drug, as small as 0.08 milligram per kilogram may release dopamine and other catecholamines from neuronal storage sites in dogs primed with dopamine. This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism.

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