Brain Adenosine Triphosphate: Decreased Concentration Precedes Convulsions

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Science  10 Jul 1970:
Vol. 169, Issue 3941, pp. 206-208
DOI: 10.1126/science.169.3941.206


The concentration of adenosine triphosphate in the brain decreased before the onset of generalized convulsions in unanesthetized rats subjected to acute hypoxia or treated with hydroxylamine or pentylenetetrazole (Metrazol). As the convulsive episode continued, adenosine triphosphate decreased further. Stimulation of adenosine triphosphate production forestalled its disappearance from the brain and delayed the development of seizure activity.

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