Alcohol Oxidation in Rats Inhibited by Pyrazole, Oximes, and Amides

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Science  17 Jul 1970:
Vol. 169, Issue 3942, pp. 282-284
DOI: 10.1126/science.169.3942.282


Pyrazole, previously reported to inhibit ethanol oxidation in the rat, also effectively blocks the in vivo metabolism of methanol, propanol, isopropanol, n-butanol, and isobutanol. A variety of oximes and amides are also effective inhibitors of ethanol metabolism. These various inhibitors may prove important in the elucidation of several facets of alcohol metabolism and also may have application in the treatment of methanol poisoning and in the reduction of the sequelae of the disulfiram-ethanol reaction syndrome in man.

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