Plasmodium falciparum in Owl Monkeys: Drug Resistance and Chloroquine Binding Capacity

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Science  17 Jul 1970:
Vol. 169, Issue 3942, pp. 289-290
DOI: 10.1126/science.169.3942.289


Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 107 liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.

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