Hemoglobin Interaction: Modification of Solid Phase Composition in the Sickling Phenomenon

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Science  24 Jul 1970:
Vol. 169, Issue 3943, pp. 375-377
DOI: 10.1126/science.169.3943.375


Direct analyses of solid phase formed by deoxygenating solutions of sickle-cell hemoglobin (Hb S) in the presence of certain other hemoglobin species show that hemoglobins A and C can participate in the filamentous fine structure characteristic of the sickling phenomenon. In contrast, fetal hemoglobin (Hb F) is nearly completely excluded.

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