Divergent Biological Effects of Adenosine and Dibutyryl Adenosine 3',5'-Monophosphate on the Isolated Fat Cell

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Science  24 Jul 1970:
Vol. 169, Issue 3943, pp. 387-388
DOI: 10.1126/science.169.3943.387


Adenosine 3',5'-monophosphate stimulated production of carbon dioxide and lipid from glucose, whereas its dibutyryl derivative inhibited this conversion. Addition of the dibutyryl derivative to the isolated fat cell further stimulated lipolysis induced by adrenocorticotropic hormone, whereas addition of adenosine 3',5'-monophosphate inhibited this lipolysis. Hence, measured by these two parameters, the biologic properties of adenosine 3',5'-monophosphate and its dibutyryl derivative are distinctly different.

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