Allopurinol: Alteration in Pyrimidine Metabolism in Man

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Science  24 Jul 1970:
Vol. 169, Issue 3943, pp. 388-390
DOI: 10.1126/science.169.3943.388


In addition to its well-established inhibitory effect on uric acid synthesis, allopurinol appears to alter substantially pyrimidine metabolism, as evidenced by a striking increase in the urinary excretion of orotidine and orotic acid. Allopurinol ribonucleotide and xanthosine 5'-monophosphate are potent inhibitors of human erythrocyte orotidylic decarboxylase and provide a possible mechanism for this effect.