Visualization of Bacterial Genes in Action

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Science  24 Jul 1970:
Vol. 169, Issue 3943, pp. 392-395
DOI: 10.1126/science.169.3943.392


The morphology of active structural and putative ribosomal RNA genes was observed by electron microscopy after lysis of fragile Escherichia coli cells. Conclusions drawn are: most of the chromosome is not genetically active at any one instant; translation is completely coupled with transcription; the 16S and 23S ribosomal RNA cistrons occur in tandem, in regions which are widely spaced on the chromosome.

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