Fetal Kidney in Organ Culture: Abnormalities of Development Induced by Decreased Amounts of Potassium

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Science  31 Jul 1970:
Vol. 169, Issue 3944, pp. 485-487
DOI: 10.1126/science.169.3944.485


Kidneys from fetal mice (10 to 18 days' gestation) were grown in organ culture. Concentrations of potassium less than 9 milliequivalents per liter (10- to 14-day kidneys), and less than 6 milliequivalents per liter (14- to 18-day kidneys), produced abnormal branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. These studies emphasize the importance of an environment with a high concentration of potassium for development of the fetal kidney.

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