Amnesia Produced by Electroconvulsive Shock or Cycloheximide: Conditions for Recovery

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Science  14 Aug 1970:
Vol. 169, Issue 3946, pp. 683-686
DOI: 10.1126/science.169.3946.683


Retrograde amnesia for a passive avoidance response was produced in rats by electroconvulsive shock and in mice by cycloheximide, an inhibitor of protein synthesis. One day after training the memory could be restored if a "reminder" of the original foot shock was given after the retention test on which the amnesia was demonstrated. Memory did not return if the reminder was given without the prior retention test or if the reminder and the test were separated by 23 hours.

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