Cell-Mediated Immunity Shown by Lymphocytes from the Respiratory Tract

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Science  14 Aug 1970:
Vol. 169, Issue 3946, pp. 696-697
DOI: 10.1126/science.169.3946.696


Cell-mediated immunity, as evidenced by inhibition of macrophage migration in the presence of antigen, was associated with lymphocytes obtained from the respiratory tract of guinea pigs immunized by dinitrophenylated human immunoglobulin G in nose drops, but not from those immunized parenterally. However, splenic lymphocytes from parenterally immunized animals inhibited macrophage migration while those from locally immunized animals did not.

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