Temporal Summation and Refractoriness in Hypothalamic Reward Neurons as Measured by Self-Stimulation Behavior

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Science  21 Aug 1970:
Vol. 169, Issue 3947, pp. 782-785
DOI: 10.1126/science.169.3947.782


A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of refractory periods and temporal synaptic summation. The results indicate a way of studying central neuronal processes for which the overt behavior of the animal is the dependent variable.

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