Prostaglandin Receptor Site: Evidence for an Essential Role in the Action of Luteinizing Hormone

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Science  28 Aug 1970:
Vol. 169, Issue 3948, pp. 883-886
DOI: 10.1126/science.169.3948.883


A dose-response relation was established between prostaglandins and formation of adenosine 3',5'-monophosphate in the mouse ovary. The prostaglandin antagonist, 7-oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E1, prostaglandin E2, and luteinizing hormone on adenosine 3',5'-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3',5'-monophosphate formation and steroidogenesis.

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