Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

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Science  11 Sep 1970:
Vol. 169, Issue 3950, pp. 1095-1097
DOI: 10.1126/science.169.3950.1095


Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.

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