Serotonin-Containing Neurons in Brain: Depression of Firing by Monoamine Oxidase Inhibitors

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Science  11 Sep 1970:
Vol. 169, Issue 3950, pp. 1100-1102
DOI: 10.1126/science.169.3950.1100


Monoamine oxidase inhibitors were administered to rats while the activities of single, serotonin-containing neurons of the midbrain raphe nuclei were being monitored with microelectrodes. All the inhibitors tested (pargyline, tranylcypromine, phenelzine, iproniazid) caused depression of raphe unit firing rate. The ability of monoamine oxidase inhibitors to depress raphe units was impaired by prior treatment with p-chlorophenylalanine, an inhibitor of serotonin synthesis.

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