Polypeptide with Broad Biological Activity: Isolation from Small Intestine

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Science  18 Sep 1970:
Vol. 169, Issue 3951, pp. 1217-1218
DOI: 10.1126/science.169.3951.1217


A polypeptide, which has potent and diverse biological action—including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia—was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.

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