Retrograde Amnesia: Production of Skeletal but Not Cardiac Response Gradient by Electroconvulsive Shock

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Science  18 Sep 1970:
Vol. 169, Issue 3951, pp. 1224-1226
DOI: 10.1126/science.169.3951.1224


Rats given a single electroconvulsive shock immediately after but not 60 seconds after an aversive conditioning trial exhibited behavioral retention deficits 24 hours later in a one-trial passive avoidance task. In contrast to these differential performance deficits, similar heart-rate changes, indicative of fear retention, were seen in punished animals irrespective of the time of delivery of the shock. These data suggest retention of a generalized fear to the training experience that was not revealed by the behavioral measure. The potential usefulness of concomitant behavioral and physiological response assessment in consolidation research is discussed.