Pregnancies after Chemotherapy of Trophoblastic Neoplasms

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Science  25 Sep 1970:
Vol. 169, Issue 3952, pp. 1326-1327
DOI: 10.1126/science.169.3952.1326


We have analyzed 88 pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present.

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