Teratogenicity of Vitamin B6 Deficiency: Omphalocele, Skeletal and Neural Defects, and Splenic Hypoplasia

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Science  25 Sep 1970:
Vol. 169, Issue 3952, pp. 1329-1330
DOI: 10.1126/science.169.3952.1329


Vitamin B6 deficiency was induced in pregnant rats with a deficient diet and with 4-deoxypyridoxine, a B6 antagonist. Treated animals developed typical skin changes of B6 deficiency. Fetuses were small and appeared anemic. Major fetal malformations were omphalocele, exencephaly, cleft palate, micrognathia, digital defects, and splenic hypoplasia. This teratologic system was developed as a model for human syndromes that exhibit combined immunologic and neurologic or skeletal defects.

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