Intestinal Hydrolysis and Conjugation of a Pesticidal Carbamate in vitro

See allHide authors and affiliations

Science  02 Oct 1970:
Vol. 170, Issue 3953, pp. 77-78
DOI: 10.1126/science.170.3953.77


The metabolite 1-[1-14C]naphthyl glucuronide was isolated from mucosal and serosal fluids of everted sacs of rat small intestine incubated in media containing either the insecticide 1-[1-14C]naphthyl N-methylcarbamate (carbaryl) or 1-[1-14C]naphthol. The hydrolysis of carbaryl and conjugation of the liberated naphthol indicated some degree of metabolism by the intestine before absorption.

Stay Connected to Science