Reduced Nicotinamide-adenine Dinucleotide Phosphate Oxidase: Activity Enhanced by Ethanol Consumption

See allHide authors and affiliations

Science  02 Oct 1970:
Vol. 170, Issue 3953, pp. 78-80
DOI: 10.1126/science.170.3953.78


Prolonged consumption of ethanol enhances the activities of the hepatic microsomal ethanol oxidizing system and of reduced nicotinamide-adenine dinucleotide phosphate oxidase, but not of catalase. The oxidase-catalase system is not part of the microsomal ethanol oxidizing system since catalase inhibitors dissociate ethanol oxidation by the two pathways. Enhanced reduced nicotinamide-adenine dinucleotide phosphate oxidase activity may contribute to liver injury, possibly by favoring lipoperoxidation.

Stay Connected to Science