Aspirin: Intestinal Damage in Rats

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Science  09 Oct 1970:
Vol. 170, Issue 3954, pp. 183-185
DOI: 10.1126/science.170.3954.183


Lesions induced by aspirin in the small intestine of the rat were visualized after 4 hours by the intravenous administration of a 5 percent solution of pontamine sky blue, 6 BX dye. Dose-response curves in fasted and fed rats indicated that the fed rat was about eight times more susceptible to aspirin-induced intestinal damage than was the fasted rat, while the fasted rat was about 13 times more susceptible to aspirin-induced gastric damage than was the fed rat.

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