Strain C3H-AvyfB Mice: Ninety Percent Incidence of Mammary Tumors Transmitted by Either Parent

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Science  09 Oct 1970:
Vol. 170, Issue 3954, pp. 185-187
DOI: 10.1126/science.170.3954.185


Mammary tumorigenesis in C3H-AvyfB female mice is not due to milk-borne mammary tumor virus but to factors transmitted at conception. Prominent among these is the Avy gene which may increase the virulence or transmissibility of a variant of mammary tumor virus vertically transmitted by either parent, or may increase the tumorigenic response of the mammary tissue. These factors together with the influence of hormones of pregnancy resulted in the high incidence observed.

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