Chemically Induced Porphyria: Prevention by Prior Treatment with Phenobarbital

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Science  16 Oct 1970:
Vol. 170, Issue 3955, pp. 320-322
DOI: 10.1126/science.170.3955.320


The excessive induction of hepatic δ-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital. Studies in vivo and in vitro indicate that phenobarbital prevents the induction of chemical porphyria by increasing the rate of detoxification of inducers by way of drug-metabolizing enzymes of the hepatic endoplasmic reticulum.

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