Shear Degradation of Fibrinogen in the Circulation

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Science  23 Oct 1970:
Vol. 170, Issue 3956, pp. 466-468
DOI: 10.1126/science.170.3956.466


Plasma fibrinogen in vitro suffers a loss in clottability due to shearing. From calculation of the mass average shear to which plasma is subjected in the circulation, it is estimated that the half-life of fibrinogen is 4 days. This is in excellent agreement with reports that the half-life of fibrinogen in the circulatory system is 4 to 5 days. Hence shearing may be the mechanism for fibrinogen degradation in the circulatory system.

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