Norepinephrine Metabolism in Brainstem of Spontaneously Hypertensive Rats

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Science  30 Oct 1970:
Vol. 170, Issue 3957, pp. 544-546
DOI: 10.1126/science.170.3957.544


Concentrations of norepinephrine in lower brainstem and hypothalamus of genetically hypertensive rats are significantly lower than in control rats. There is a concomitant reduction (50 percent) in aromatic L-amino acid decarboxylase but not in tyrosine hydroxylase activity. A possible relation of this central catecholamine deficiency to the hypertension is discussed.

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