Soluble HL-A7 Antigen: Localization in the β-Lipoprotein Fraction of Human Serum

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Science  06 Nov 1970:
Vol. 170, Issue 3958, pp. 636-637
DOI: 10.1126/science.170.3958.636


The HL-A7 antigen of human leukocytes occurs as a soluble, low-density lipoprotein in the serum of HL-A7-positive individuals. Its presence in high concentration may inhibit direct leukocyte grouping, leading to erroneous results. This finding affords an easy method for the preparation of monospecific cytotoxic antiserums by absorption with serum fractions rather than leukocytes.

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