Secondary Structure of Ribosomal RNA

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Science  13 Nov 1970:
Vol. 170, Issue 3959, pp. 740-741
DOI: 10.1126/science.170.3959.740


Infrared spectra were obtained for 16S and for 23S ribosomal RNA's in D2O solutions. The percentage of each base in the paired and unpaired regions of the RNA was determined from the spectra. The secondary structures of 16S and 23S ribosomal RNA's (from Escherichia coli) are significantly different from each other and are also different from those of yeast ribosomal RNA, formylmethionyl-transfer RNA, and the anticodon fragment of this transfer RNA.

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