Transfer of Interferon-Producing Macrophages: New Approach to Viral Chemotherapy

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Science  20 Nov 1970:
Vol. 170, Issue 3960, pp. 854-856
DOI: 10.1126/science.170.3960.854


Mice were protected from infection with Semliki Forest virus and encephalomyocarditis virus by the transfer of peritoneal macrophages that were stimulated to produce interferon in vitro by exposure to a nonreplicating virus. This method of therapy was also utilized in animals infected with encephalomy-ocarditis virus after onset of clinical signs. Of these animals 40 percent recovered, but only 9 percent of the control group recovered.

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