Vascular Lesions: Possible Pathogenetic Basis of the Generalized Shwartzman Reaction

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Science  27 Nov 1970:
Vol. 170, Issue 3961, pp. 986-988
DOI: 10.1126/science.170.3961.986


Evidence of vascular injury was found in rabbits after a single small dose of endotoxin from Escherichia coli. Eighty percent of the treated animals developed circulating endothelial cells, leukopenia, and thrombocytopenia, and 50 percent had aortic endothelial lesions as determined by electron microscopy. Prior anticoagulation with heparin did not prevent this response. No control animals showed these abnormalities.

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