Antigen-Binding Cells in Normal Mouse Thymus

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Science  04 Dec 1970:
Vol. 170, Issue 3962, pp. 1102-1104
DOI: 10.1126/science.170.3962.1102


The thymus of a normal adult mouse contains lymphocytic cells with a large number of antigen-binding receptors. Binding of the antigen by these cells is specific and can be inhibited by cross-reactive materials. It is possible that the interaction of thymocytes with antibody-forming precursor cells, required in the primary immune response to certain antigens, is mediated by these specific antigen-binding cells of the thymus.

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