Molecular Microscopy: Fundamental Limitations

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Science  18 Dec 1970:
Vol. 170, Issue 3964, pp. 1310-1313
DOI: 10.1126/science.170.3964.1310


On the basis of estimates of molecular damage caused by the observation process, it is concluded that molecular microscopy of biological molecules in which the individual atoms are resolved is impossible with an electron or x-ray microscope. Microscopes that use low-energy helium atoms or neutrons as illuminants may be capable of serving as ultimate biomolecular microscopes.

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