Microcytotoxicity Test: Detection in Sarcoma Patients of Antibody Cytotoxic to Human Sarcoma Cells

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Science  18 Dec 1970:
Vol. 170, Issue 3964, pp. 1318-1320
DOI: 10.1126/science.170.3964.1318


A microcytotoxicity test has been used to detect a factor cytotoxic for human sarcoma cells; the factor was found in serums from 70 percent of sarcoma patients, 58 percent of their family members, and 8 percent of serums from normal blood donors. This cytotoxin is an antibody against a common cell surface sarcoma antigen since it is specific for sarcoma cells, is complement dependent, and is extractable with the globulin fraction of serum.