Marihuana: Studies on the Disposition and Metabolism of Delta-9-Tetrahydrocannabinol in Man

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Science  18 Dec 1970:
Vol. 170, Issue 3964, pp. 1320-1322
DOI: 10.1126/science.170.3964.1320


Δ9-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t1/2 = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Δ9-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days.

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