Cerebellar Hypoplasia in Neonatal Rats Caused by Lymphocytic Choriomeningitis Virus

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Science  15 Jan 1971:
Vol. 171, Issue 3967, pp. 194-196
DOI: 10.1126/science.171.3967.194


Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rodents.

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