Epithelial Origin of Polyoma Salivary Tumors in Mice: Evidence Based on Chromosome-Marked Cells

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Science  29 Jan 1971:
Vol. 171, Issue 3969, pp. 394-397
DOI: 10.1126/science.171.3969.394


Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T6 chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of classical problems concerning epithelial as opposed to mesenchymal origin of neoplasms.

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