Synergy of Ethanol and a Natural Soporific—Gamma Hydroxybutyrate

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Science  29 Jan 1971:
Vol. 171, Issue 3969, pp. 404-406
DOI: 10.1126/science.171.3969.404


γ-Hydroxybutyrate and ethanol, as well as γ-butyrolactone and ethanol are potentiative with respect to duration of loss of the righting reflex (sleep time). The concentration of ethanol in the liver decreases from 30 to 90 minutes after rats are injected with ethanol, but there is no change when ethanol is injected with γ-butyrolactone. In view of the fact that γ-hydroxybutyrate is a natural intermediate in brain, the effects of ethanol on the central nervous system may be mediated through its interaction with γ-butyrolactone.

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