Favism: Association with Erythrocyte Acid Phosphatase Phenotype

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Science  29 Jan 1971:
Vol. 171, Issue 3969, pp. 409-411
DOI: 10.1126/science.171.3969.409


The frequency of carriers of the Paand Pc alleles of the gene for acid phosphatase in the erythrocyte is significantly higher in male subjects deficient in glucose-6-phosphate dehydrogenase and having hemolytic clinical favism than it is in the general population. This observation seems to indicate that alleles (Pa and Pc) of a gene polymorphic in all human populations affect the fitness of the involved phenotypes in special genotypic and nongenotypic conditions.

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