A Portal Blood Factor as the Humoral Agent in Liver Regeneration

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Science  12 Feb 1971:
Vol. 171, Issue 3971, pp. 575-577
DOI: 10.1126/science.171.3971.575


It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl-3H]- thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted,partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.

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