Subunit Structure of Aldolase

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Science  19 Feb 1971:
Vol. 171, Issue 3972, pp. 677-680
DOI: 10.1126/science.171.3972.677


A new crystal form of rabbit muscle aldolase shows that the molecule has 222 symmetry to at least 4-angstrom resolution, and hence that the gross conformation of the four subunits is the same. Comparison of the new form with a previously reported form establishes the number of molecules per unit cell, n, in the older form. For an independent check, the "crystal-volume and protein-content method" was developed to determine n without directly measuring the water content of the crystals.

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