Ethacrynic Acid Effect on the Composition of Cochlear Fluids

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Science  05 Mar 1971:
Vol. 171, Issue 3974, pp. 910-911
DOI: 10.1126/science.171.3974.910


Ethacrynic acid, when administered to six dogs, caused a fall in the concentration of potassium in endolymph from 145 to 21 milliequivalents per liter and a rise in the concentration of sodium from 5.9 to 146 milliequivalents per liter. The composition of perilymph is unaffected. Perilymph and endolymph are slightly hypertonic as compared to plasma.