Scanning Electron Microscopic Observations of Surface Structure of Isolated Human Chromosomes

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Science  12 Mar 1971:
Vol. 171, Issue 3975, pp. 1024-1026
DOI: 10.1126/science.171.3975.1024


Isolated human chromosomes dried by the critical-point method have been assumed to retain their original three-dimensional shape when viewed under a transmission electron microscope. Our scanning electron microscopic study confirms this interpretation and reveals an appearance like that of a skein of yarn. The existence of fiber bridges between chromatid pairs and among chromosomes is demonstrated.

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