Adenosine 3',5'-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission

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Science  19 Mar 1971:
Vol. 171, Issue 3976, pp. 1156-1158
DOI: 10.1126/science.171.3976.1156


Brief periods of stimulation of the preganglionic nerve fibers produced a severalfold increase in the content of adenosine 3',5'-monophosphate in superior cervical sympathetic ganglia, whereas postganglionic stimulation did not. These and other experiments indicated that the increased concentrations of adenosine 3'5'-monophosphate were closely associated with the process of synaptic transmission. This increase occurred primarily in postsynaptic cells.

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