Synaptic Facilitation: Long-Term Neuromuscular Facilitation in Crustaceans

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Science  26 Mar 1971:
Vol. 171, Issue 3977, pp. 1248-1250
DOI: 10.1126/science.171.3977.1248


Continuous stimulation at frequencies equal to or greater than 5 hertz for 20 to 30 minutes results in a two- to fivefold increase in the amplitudes of excitatory postsynaptic potential recorded from certain stretcher and opener muscles of decapod crustaceans. This long-term facilitation appears to result from an accumulation of sodium ions within the nerve terminals. It persists for at least 1 hour after stimulation has stopped.

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